Tabersonine attenuates Angiotensin II-induced cardiac remodeling and dysfunction through targeting TAK1 and inhibiting TAK1-mediated cardiac inflammation
Chengyi Dai, Wu Luo, Yanghao Chen, Siyuan Shen, Zhe Wang, Ruijie Chen, Jun Wang, Nipon Chattipakorn, Weijian Huang, Guang Liang
Topics & Concepts
InflammationAngiotensin IIFibrosisPharmacologyCardiac fibrosisHeart failureMedicineVentricular remodelingp38 mitogen-activated protein kinasesCardiac function curveGene knockdownIn vivoMAPK/ERK pathwayChemistryInternal medicineKinaseBiologyReceptorBiochemistryBiotechnologyApoptosisCardiac Fibrosis and RemodelingCardiac electrophysiology and arrhythmiasNF-κB Signaling Pathways