A small molecule nanodrug consisting of pH-sensitive ortho ester–dasatinib conjugate for cancer therapy
Jialu Gao, Zhen Qiao, Shuo Liu, Jiaxi Xu, Wang Shi, Xia Yang, Xin Wang, Rupei Tang
Topics & Concepts
ProdrugDasatinibConjugateDoxorubicinChemistryInternalizationDrug deliveryIn vivoIn vitroSmall moleculeNanoparticleBiophysicsDrugHydrolysisCombinatorial chemistryPharmacologyStereochemistryNanotechnologyBiochemistryChemotherapyOrganic chemistryMaterials scienceMedicineReceptorMathematical analysisSurgeryTyrosine kinaseBiologyMathematicsBiotechnologyNanoparticle-Based Drug DeliveryRNA Interference and Gene DeliveryDendrimers and Hyperbranched Polymers