Cartilage regeneration using transforming growth factor-beta 3-loaded injectable crosslinked hyaluronic acid hydrogel
Ju Hwa Lee, Pil Yun Kim, Yun Chang Pyun, Jong‐Gyu Park, Tae Woong Kang, Jin Sol Seo, Dae Hoon Lee, Gilson Khang
Abstract
. Finally, HAT combined with microfracture-inducing bone marrow stem cells could significantly improve the cartilage microenvironment and regeneration of cartilage defects. Our results indicate that HA is a suitable material for developing growth factor carriers, whereas HAT is a promising candidate for cartilage regeneration. Furthermore, this differentiated strategy provides a rapid and effective clinical approach for next-generation cartilage regeneration.
Topics & Concepts
Hyaluronic acidRegeneration (biology)Self-healing hydrogelsChemistryCartilageGrowth factorArticular cartilageBiophysicsBiomedical engineeringCell biologyPolymer chemistryBiochemistryOsteoarthritisAnatomyPathologyBiologyMedicineAlternative medicineReceptorOsteoarthritis Treatment and MechanismsPeriodontal Regeneration and TreatmentsProteoglycans and glycosaminoglycans research