A two-photon fluorescent probe for sensitive detection and imaging of γ-glutamyl transpeptidase
Ruijin Huo, Xiuli Zheng, Weimin Liu, Liping Zhang, Jiasheng Wu, Li Fan, Wenjun Zhang, Chun‐Sing Lee, Pengfei Wang
Abstract
A GGT-activated two-photon fluorescent probe (4F-2CN-GSH) was developed based on a cascade reaction. 4F-2CN-GSH could selectivily detect GGT with low detection limit and distinguish ovarian cancer cells from normal cells using both one-photon and two-photon fluorescence imaging.
Topics & Concepts
FluorescenceTwo-photon excitation microscopyOvarian cancerChemistryBiophysicsPathologyCancerBiologyMedicineOpticsPhysicsInternal medicineNanoplatforms for cancer theranosticsLuminescence and Fluorescent MaterialsSulfur Compounds in Biology