Antiviral activity of chitosan nanoparticles encapsulating silymarin (Sil–CNPs) against SARS-CoV-2 (<i>in silico</i> and <i>in vitro</i> study)
Samah A. Loutfy, Ahmed I. Abdel-Salam, Yassmin Moatasim, Mokhtar R. Gomaa, Nasra F. Abdel Fattah, Merna H. Emam, Fedaa Ali, Hasnaa A. ElShehaby, Eman A. Ragab, Hanaa M. Alam El-Din, Ahmed Mostafa, Mohamed A. Ali, Amal Kasry
Abstract
in virucidal/replication assays for CNPs, Sil, and Sil-CNPs respectively using crystal violet. These results indicate antiviral activity of Sil-CNPs against SARS-CoV-2.
Topics & Concepts
In silicoIn vitroChemistrySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)ChitosanVirologyPharmacologyCombinatorial chemistryMedicineBiochemistryPathologyDiseaseInfectious disease (medical specialty)GeneSARS-CoV-2 and COVID-19 ResearchAntibiotics Pharmacokinetics and EfficacyVenomous Animal Envenomation and Studies