The IgA-pIgR System Is Dysregulated in Idiopathic Pulmonary Fibrosis
Thomas Planté-Bordeneuve, Youri Bertrand, Marylène Lecocq, Delphine Hoton, Catherine Fillée, Valérie Lacroix, Benoı̂t Rondelet, Wim Wuyts, Caroline Bouzin, Charles Pilette, Antoine Froidure
Abstract
To the Editor: Idiopathic pulmonary fibrosis (IPF) lungs display aberrant epithelial structures, namely honeycomb cysts (HC), lined by a bronchiolized epithelium and filled with mucus-like secretions, and hyperplasic type 2 alveolar epithelial cell cysts. The recent discovery of pathological bronchial epithelial cell subpopulations in IPF, together with mucosal immunity modifications, further questions the role of these structures. [...]
Topics & Concepts
MedicineImmunologyImmunodeficiency and Autoimmune DisordersImmune Cell Function and InteractionT-cell and B-cell Immunology