Bulleyaconitine A is a sensitive substrate and competitive inhibitor of CYP3A4: One of the possible explanations for clinical adverse reactions
Xiaocui Li, Xiaowen Ou, Jiadong Ni, Yihong Xu, Zuo Huilin, Yu Fu, Caihua Yang, Zhongxiang Zhao, Na Li, Hua Zhou, Rong Zhang, Zhongqiu Liu, Ling Fu, Lijun Zhu
Topics & Concepts
CYP3A4PharmacologyCYP3AChemistryCytochrome P450CYP1A2Non-competitive inhibitionEnzymeMicrosomeKetoconazoleCYP2B6Mechanism of actionDrug metabolismMetaboliteIn vitroBiochemistryBiologyMicrobiologyAntifungalPlant-based Medicinal ResearchPharmacogenetics and Drug MetabolismPharmacological Effects of Natural Compounds