Defining the Selectivity of Chemical Inhibitors Used for Cytochrome P450 Reaction Phenotyping: Overcoming Selectivity Limitations with a Six-Parameter Inhibition Curve-Fitting Approach
Angela C. Doran, Woodrow Burchett, Connor Landers, Gabrielle M. Gualtieri, Amanda Balesano, Heather Eng, Alyssa Dantonio, Theunis C. Goosen, R. Scott Obach
Topics & Concepts
ChemistryCytochrome P450SelectivityCYP1A2CYP3A4QuinidineKetoconazolePharmacologyEnzymeCYP2C19BiochemistryStereochemistryBiologyCatalysisMicrobiologyAntifungalPharmacogenetics and Drug MetabolismAnalytical Chemistry and ChromatographyComputational Drug Discovery Methods