Iron-Catalyzed Alkyne-Based Multicomponent Synthesis of Pyrimidines under Air
Rakesh Mondal, Gargi Chakraborty, Amit Kumar Guin, Susmita Sarkar, Nanda D. Paul
Abstract
An iron-catalyzed sustainable, economically affordable, and eco-friendly synthetic protocol for the construction of various trisubstituted pyrimidines is described. A wide range of trisubstituted pyrimidines were prepared using a well-defined, easy to prepare, bench-stable, and phosphine-free iron catalyst featuring a redox-noninnocent tridentate arylazo pincer under comparatively mild aerobic conditions via dehydrogenative functionalization of alcohols with alkynes and amidines.
Topics & Concepts
CatalysisPhosphineAlkyneChemistryCombinatorial chemistrySurface modificationPincer movementOrganic chemistryPhysical chemistryAsymmetric Hydrogenation and CatalysisChemical Synthesis and AnalysisCatalytic C–H Functionalization Methods