Exogenous bone marrow derived-putative endothelial progenitor cells attenuate ischemia reperfusion-induced vascular injury and renal fibrosis in mice dependent on pericytes
Meng Wang, Huzi Xu, Yinzheng Li, Chujin Cao, Han Zhu, Di Wang, Zhi Zhao, Guangchang Pei, Fan Zhu, Qian Yang, Xuan Deng, Cheng Zhou, Yi Guo, Jianliang Wu, Wenhui Liao, Juan Yang, Ying Yao, Rui Zeng
Abstract
Exogenous b-pEPCs directly protect against IR-induced vascular injury and prevent renal fibrosis by inhibiting the activation of PDGFR-β-positive pericytes.
Topics & Concepts
PericyteMural cellMyofibroblastFibrosisRenal ischemiaMedicineProgenitor cellAngiogenesisIschemiaPlatelet-derived growth factor receptorKidneyBone marrowPathologyParacrine signallingCancer researchEndothelial stem cellGrowth factorReperfusion injuryBiologyCell biologyInternal medicineStem cellVascular smooth muscleReceptorSmooth muscleBiochemistryIn vitroAngiogenesis and VEGF in CancerRenal cell carcinoma treatmentRenal and Vascular Pathologies