<i>APOE</i> genotype regulates pathology and disease progression in synucleinopathy
Albert A. Davis, Casey E. Inman, Zachary M. Wargel, Umber Dube, Brittany M. Freeberg, Alexander Galluppi, Jessica N. Haines, Dhruva D. Dhavale, Rebecca L. Miller, Fahim A. Choudhury, Patrick M. Sullivan, Carlos Cruchaga, Joel S. Perlmutter, Jason D. Ulrich, Bruno A. Benítez, Paul T. Kotzbauer, David M. Holtzman
Abstract
APOE genotype regulates disease development in mouse models of α-synucleinopathy and affects cognition in patients with Parkinson’s disease.
Topics & Concepts
Apolipoprotein EDiseaseGenotypePathologyMedicineBiologyGeneticsGeneParkinson's Disease Mechanisms and TreatmentsNuclear Receptors and SignalingGinkgo biloba and Cashew Applications