Efficient development of sorafenib tablets with improved oral bioavailability enabled by coprecipitated amorphous solid dispersion
Sichen Song, Chenguang Wang, Shan Wang, Ronald A. Siegel, Changquan Calvin Sun
Topics & Concepts
BioavailabilityFriabilityCoprecipitationGranulationAmorphous solidMaterials scienceDosage formDissolutionDispersion (optics)ChromatographyNuclear chemistryPharmacologyChemistryMedicineFirst pass effectOrganic chemistryComposite materialPhysicsOpticsDrug Solubulity and Delivery SystemsProtein purification and stabilityCrystallization and Solubility Studies