Iridium-Catalyzed Cyclative Indenylation and Dienylation through Sequential B(4)–C Bond Formation, Cyclization, and Elimination from <i>o</i>-Carboranes and Propargyl Alcohols
Yonghyeon Baek, Kiun Cheong, Gi Hoon Ko, Gi Uk Han, Sang Hoon Han, Dongwook Kim, Kooyeon Lee, Phil Ho Lee
Abstract
Described herein is the first iridium-catalyzed cyclative indenylation through sequential B(4)–C and intramolecular C–C bond formation from o-carboranes and propargyl alcohols, leading to the formation of B(4)-indenylated o-carboranes with excellent regioselectivity via direct B–H activation. Moreover, the iridium-catalyzed regioselective 1,3-dienylation has been accessed through sequential B–H activation, dehydration, and decarboxylation, producing B(4)-dienylated o-carboranes.
Topics & Concepts
ChemistryRegioselectivityIridiumPropargylIntramolecular forceDecarboxylationCatalysisMedicinal chemistryTriple bondStereochemistryDouble bondOrganic chemistryBoron Compounds in ChemistryOrganoboron and organosilicon chemistryOrthopedic Infections and Treatments