Combination of metformin and hesperidin mitigates cyclophosphamide-induced hepatotoxicity. Emerging role of PPAR-γ/Nrf-2/NF-κB signaling pathway
Kareman M. El-Beheiry, Magda El‐Sayed El‐Sayad, Thanaa A. El‐Masry, Alaa E. El‐Sisi
Topics & Concepts
PharmacologyOxidative stressHesperidinMetforminMalondialdehydeApoptosisGlutathioneMedicineNF-κBPeroxisome proliferator-activated receptorBilirubinChemistryLiver functionInternal medicineEndocrinologyInflammationReceptorDiabetes mellitusBiochemistryPathologyEnzymeAlternative medicineChemotherapy-induced organ toxicity mitigationDrug-Induced Hepatotoxicity and ProtectionChildhood Cancer Survivors' Quality of Life