The roles and regulation of the KLF5 transcription factor in cancers
Yao Luo, Ceshi Chen
Abstract
Krüppel-like factor 5 (KLF5) is a member of the KLF family. Recent studies have suggested that KLF5 regulates the expression of a large number of new target genes and participates in diverse cellular functions, such as stemness, proliferation, apoptosis, autophagy, and migration. In response to multiple signaling pathways, various transcriptional modulation and posttranslational modifications affect the expression level and activity of KLF5. Several transgenic mouse models have revealed the physiological and pathological functions of KLF5 in different cancers. Studies of KLF5 will provide prognostic biomarkers, therapeutic targets, and potential drugs for cancers.
Topics & Concepts
Transcription factorCancer researchBiologyAutophagyKrüppelGeneTransgeneEctopic expressionPathologicalCell biologyApoptosisGeneticsMedicineInternal medicineKruppel-like factors researchCancer-related gene regulationGenetic Syndromes and Imprinting