Design and Rapid Microwave Irradiated One-Pot Synthesis of Tetrahydropyrimidine Derivatives and Their Screening <i>In Vitro</i> Antidiabetic Activity
Jaydeep Lalpara, Sanjay Hadiyal, Ashish radia, Jayesh Dhalani, G. G. Dubal
Abstract
A rapid and efficient method has been developed for one-pot synthesis of some newly designed tetrahydropyrimidine derivatives with aid of 1,3,4-oxadiazole containing aldehyde, substituted acetoacetanilide and thiourea/guanidine in the occurrence of microwave irradiation. The significant yield of products, atom economy, less time consuming, and catalyst-free synthesis were considered preferences of microwave irradiation. All synthesized compounds were characterized by 1H NMR, 13C NMR, IR, and mass spectrometry techniques. All synthesized compounds were evaluated bioassay for in vitro antidiabetic screening viz α-amylase inhibition strategy and checked their potency against standard reference drug acarbose.