Inhibition of the BTK-IDO-mTOR axis promotes differentiation of monocyte-lineage dendritic cells and enhances anti-tumor T cell immunity
Madhav Sharma, Rafał Pacholczyk, Huidong Shi, Zuzana Berrong, Yousef Zakharia, Austin Greco, Chang-Sheng S. Chang, Sudharshan Eathiraj, Eugene P. Kennedy, Thomas F. Cash, Roni J. Bollag, Ravindra Kolhe, Ramses Sadek, Tracy L. McGaha, Paulo C. Rodrı́guez, Jay K. Mandula, Bruce R. Blazar, Theodore S. Johnson, David H. Munn
Topics & Concepts
BiologyLineage (genetic)ImmunityMonocyteBruton's tyrosine kinasePI3K/AKT/mTOR pathwayImmunologyCancer researchCell biologyCell lineageCellular differentiationImmune systemGeneticsSignal transductionGeneTyrosine kinaseImmune Cell Function and InteractionImmunotherapy and Immune ResponsesCancer Immunotherapy and Biomarkers