Bazedoxifene-induced ROS promote mitochondrial dysfunction and enhance osimertinib sensitivity by inhibiting the p-STAT3/SOCS3 and KEAP1/NRF2 pathways in non-small cell lung cancer
Yunchong Meng, Wei Lin, Na Wang, Wei Xiao, Quanfu Huang, Yongde Liao
Topics & Concepts
Cancer researchOsimertinibLung cancerKEAP1ChemistrySTAT3ApoptosisBiologyCancerMedicineOncologyInternal medicineBiochemistryAdenocarcinomaGeneROS1Transcription factorLung Cancer Treatments and MutationsCytokine Signaling Pathways and InteractionsGenomics, phytochemicals, and oxidative stress