Lgr5 Marks Adult Progenitor Cells Contributing to Skeletal Muscle Regeneration and Sarcoma Formation
Carly Leung, Katzrin Bte Ahmad Murad, Adelyn Liang Thing Tan, Swathi Yada, Sowmya Sagiraju, Peter K. Bode, Nick Barker
Abstract
Satellite cells are a heterogeneous population activated upon skeletal muscle injury. In this study, Leung et al. demonstrate that Lgr5 is upregulated in progenitor cells upon muscle injury, contributing to muscle regeneration and replenishment of the satellite cell pool. Moreover, we show that Lgr5 + cells are cell of origin of sarcomas.
Topics & Concepts
LGR5Skeletal muscleStem cellWnt signaling pathwayBiologyRegeneration (biology)Progenitor cellCell biologyCardiotoxinPopulationAdult stem cellCancer researchImmunologyEndothelial stem cellAnatomyCancer stem cellSignal transductionMedicineGeneticsIn vitroEnvironmental healthMuscle Physiology and DisordersTissue Engineering and Regenerative MedicinePluripotent Stem Cells Research