Loss of SIRT4 promotes the self-renewal of Breast Cancer Stem Cells
Lutao Du, Xiaoyan Liu, Yidan Ren, Juan Li, Peilong Li, Qinlian Jiao, Peng Meng, Fang Wang, Yuli Wang, Yunshan Wang, Chuanxin Wang
Abstract
These results demonstrate that SIRT4 exerts its tumor-suppressive activity via modulating SIRT1 expression in breast cancer and provide a novel cross-talk between mitochondrial and nuclear sirtuins.
Topics & Concepts
Breast cancerBiologyCancer researchSirtuinCancerStem cellSIRT6CarcinogenesisCancer cellCancer stem cellNAD+ kinaseCell biologyBiochemistryGeneticsEnzymeSirtuins and Resveratrol in MedicineAdipose Tissue and MetabolismAutophagy in Disease and Therapy