Hypermutator Pseudomonas aeruginosa Exploits Multiple Genetic Pathways To Develop Multidrug Resistance during Long-Term Infections in the Airways of Cystic Fibrosis Patients
Claudia Antonella Colque, Andrea G. Albarracín Orio, Sofía Feliziani, Rasmus L. Marvig, A. R. Tobares, Helle Krogh Johansen, Søren Molin, Andrea M. Smania
Abstract
Pseudomonas aeruginosa exploits intrinsic and acquired resistance mechanisms to resist almost every antibiotic used in chemotherapy. Antimicrobial resistance in P. aeruginosa isolates recovered from cystic fibrosis (CF) patients is further enhanced by the occurrence of hypermutator strains, a hallmark of chronic infections in CF patients. However, the within-patient genetic diversity of P. aeruginosa populations related to antibiotic resistance remains unexplored.
Topics & Concepts
Pseudomonas aeruginosaBiologyAntibiotic resistanceCystic fibrosisResistomeAntibioticsGeneticsMultiple drug resistanceGeneLineage (genetic)AlleleMicrobiologyIntegronBacteriaAntibiotic Resistance in BacteriaEvolution and Genetic DynamicsCystic Fibrosis Research Advances