R13 preserves motor performance in SOD1<sup>G93A</sup> mice by improving mitochondrial function
Xiao Li, Chongyang Chen, Zhan Xu, Binyao Li, Zaijun Zhang, Shupeng Li, Yongmei Xie, Xiangrong Song, Yuanyuan Shen, Jianjun Liu, Ping Liu, Gongping Liu, Xifei Yang
Abstract
These findings suggest oral R13 treatment slowed the advance of motor system disease in a reliable animal model of ALS, supporting that R13 might be useful for treating ALS.
Topics & Concepts
Amyotrophic lateral sclerosisMitochondrial biogenesisSOD1Motor neuronSpinal cordMedicineNissl bodyNeuroregenerationTFAMMitochondrionNeurosciencePathologyBiologyInternal medicineNeuroprotectionCell biologyStainingDiseaseAmyotrophic Lateral Sclerosis ResearchHistone Deacetylase Inhibitors ResearchCholinesterase and Neurodegenerative Diseases