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EGR2 O-GlcNAcylation orchestrates the development of protumoral macrophages to limit CD8+ T cell antitumor responses

Yuchen Zhang, Hong Peng Li, Yi Hao, Jiaqi Chen, Xing Chen, Hang Yin

2025Cell chemical biology9 citationsDOI

Topics & Concepts

Cancer researchCytotoxic T cellTranscription factorReprogrammingCD8BiologyCell biologyMyeloidCellGeneImmune systemBiochemistryImmunologyIn vitroImmune cells in cancerGlycosylation and Glycoproteins ResearchRNA modifications and cancer
EGR2 O-GlcNAcylation orchestrates the development of protumoral macrophages to limit CD8+ T cell antitumor responses | Litcius