Quinine Esters with 1,2-Azole, Pyridine and Adamantane Fragments
G.K. Mukusheva, Aigerym R. Zhasymbekova, Роза Б. Сейдахметова, О. А. Нуркенов, Е. А. Akishina, С. К. Петкевич, Е. А. Дикусар, В. И. Поткин
Abstract
An efficient method of producing quinine derivatives via reaction of acylation with 4,5-dichloroisothiazole-3-, 5-arylisoxazole-3-, adamantane- and hydrochlorides of pyridine-3- and pyridine-4-carbonyl chlorides was developed. All synthesized compounds were tested for antiviral, antimicrobial and analgesic activity. The most pronounced antibacterial activity was shown by the compounds 2e, 3b, 3c and 3e with isoxazole and pyridine fragments. It was found that most of the tested compounds showed significant analgesic activity reducing the pain response of animals to the irritating effect of acetic acid.
Topics & Concepts
PyridineAdamantaneChemistryAntimicrobialAcylationAzoleAnalgesicIsoxazoleAcetic acidOrganic chemistryStereochemistryMedicinal chemistryAntifungalPharmacologyBiologyMicrobiologyCatalysisSynthesis and biological activitySynthesis and Reactions of Organic CompoundsSynthesis and Biological Evaluation