Multiparameter phenotypic screening for endogenous TFEB and TFE3 translocation identifies novel chemical series modulating lysosome function
Phillippa J. Carling, Brent J. Ryan, William McGuinness, Shikha Kataria, Stewart W. Humble, Stefan Milde, James A. Duce, Nirav Kapadia, William J. Zuercher, John B. Davis, Elena Di Daniel, Richard Wade‐Martins
Abstract
AD: Alzheimer disease; AK: adenylate kinase; CLEAR: coordinated lysosomal expression and regulation; CQ: chloroquine; HD: Huntington disease; PD: Parkinson disease; PKIS2: Published Kinase Inhibitor Set 2; PRKD: protein kinase D; TFEB: transcription factor EB.
Topics & Concepts
TFEBBiologyLysosomeNeurodegenerationTFE3Cell biologyAutophagyMechanistic target of rapamycinTranscription factorPI3K/AKT/mTOR pathwayBiochemistrySignal transductionGeneMedicineApoptosisPathologyEnhancerDiseaseEnzymeCellular transport and secretionAutophagy in Disease and TherapyEndoplasmic Reticulum Stress and Disease