Humic acid as an efficient and reusable catalyst for one pot three-component green synthesis of 5-substituted 1<i>H</i>-tetrazoles in water
Hongshe Wang, Yichun Wang, Yinfeng Han, Weixing Zhao, Xiaomei Wang
Abstract
-tetrazoles from aldehydes, hydroxyamine hydrochloride and sodium azide using humic acid as an efficient catalyst in water is described. The method reported has several advantages such as high to excellent yields, easy work-up, mild reaction conditions, use of water as a green solvent, and a commercially available, nontoxic and reusable catalyst.
Topics & Concepts
CatalysisComponent (thermodynamics)Humic acidChemistrySolid acidOne-pot synthesisOrganic chemistryCombinatorial chemistryFertilizerPhysicsThermodynamicsSynthesis of Tetrazole DerivativesMulticomponent Synthesis of HeterocyclesMicrowave-Assisted Synthesis and Applications