Clinical trials during the COVID-19 pandemic: Challenges of putting scientific and ethical principles into practice
Arun Bhatt
Abstract
Global pandemic of COVID-19 is a serious unmet medical need requiring clinical research into effective therapies. Clinical trials during pandemics of infections face complex challenges of putting scientific and ethical principles into practice. Some of these issues - selection of investigational product and participants, study design, assessment of efficacy and safety, ethics review, informed consent and publication, sample size, and publications - require in-depth consideration in planning and implementation of clinical trials during pandemics.
Topics & Concepts
Coronavirus disease 2019 (COVID-19)Pandemic2019-20 coronavirus outbreakSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Clinical trialEngineering ethicsMedicineVirologyOutbreakEngineeringPathologyInfectious disease (medical specialty)DiseaseCOVID-19 and healthcare impactsEthics in Clinical ResearchCOVID-19 Clinical Research Studies