MSstatsTMT: Statistical Detection of Differentially Abundant Proteins in Experiments with Isobaric Labeling and Multiple Mixtures
Ting Huang, Meena Choi, Manuel Tzouros, Sabrina Golling, Nikhil J. Pandya, Balázs Bánfai, Tom Dunkley, Olga Vitek
Abstract
balanced the sensitivity and the specificity of detecting differentially abundant proteins, in large-scale experiments with multiple biological mixtures.
Topics & Concepts
Isobaric processIsobaric labelingComputational biologyChemistryChromatographyBiologyMass spectrometryPhysicsTandem mass spectrometryProtein mass spectrometryThermodynamicsAdvanced Proteomics Techniques and ApplicationsStatistical Methods in Clinical TrialsGene expression and cancer classification