Biosynthesis of plant-specific alkaloids tetrahydroprotoberberines in engineered <i>Escherichia coli</i>
Wanli Zhao, Manyu Liu, Chen Shen, Kemeng Liu, Hanqing Liu, C N Ou, Wenling Dai, Xiufeng Liu, Jihua Liu
Abstract
Tetrahydroprotoberberines (THPBs) exhibit a variety of pharmacological activities however further investigation into their pharmaceutical utility is limited by the product quantity. In this paper, a greener strategy has been developed for the production of high-value THPBs.
Topics & Concepts
Escherichia coliBiochemical engineeringChemistryBiosynthesisBiotechnologyProduction (economics)Product (mathematics)BiochemistryBiologyEngineeringMathematicsEnzymeEconomicsGeometryGeneMacroeconomicsMicrobial Metabolic Engineering and BioproductionInnovative Microfluidic and Catalytic Techniques InnovationCatalysis for Biomass Conversion