OXA-48-Like β-Lactamases: Global Epidemiology, Treatment Options, and Development Pipeline
Sara E. Boyd, Alison Holmes, Richard Peck, David M. Livermore, William Hope
Abstract
Modern medicine is threatened by the rising tide of antimicrobial resistance, especially among Gram-negative bacteria, where resistance to β-lactams is most often mediated by β-lactamases. The penicillin and cephalosporin ascendancies were, in their turn, ended by the proliferation of TEM penicillinases and CTX-M extended-spectrum β-lactamases. These class A β-lactamases have long been considered the most important.
Topics & Concepts
PenicillinCephalosporinAntimicrobialMicrobiologyThreatened speciesAntibiotic resistanceAntibioticsMedicineIntensive care medicineBiologyEcologyHabitatAntibiotic Resistance in BacteriaAntibiotic Use and ResistanceAntibiotics Pharmacokinetics and Efficacy