Palladium-Catalyzed Borylative Cyclization and Cyclopropanation of Terminal Alkyne-Derived Enynes
Duhao Sun, Bing Zhou, Lanqin Liu, Xiao Yun Chen, Hong Hou, Ying Han, Chao‐Guo Yan, Yaocheng Shi, Shaoqun Zhu
Abstract
Described herein is a palladium-catalyzed borylative cyclization and cyclopropanation of terminal alkyne-derived enynes, affording borylated bicycles, fused cycles, and bridged cycles in good isolated yields. The synthetic utility of this protocol was fully demonstrated by large scale reaction and synthetic derivatization of the borate group.
Topics & Concepts
CyclopropanationAlkyneChemistryPalladiumCatalysisDerivatizationTerminal (telecommunication)Combinatorial chemistryOrganic chemistryHigh-performance liquid chromatographyTelecommunicationsComputer scienceCyclopropane Reaction MechanismsCatalytic C–H Functionalization MethodsCatalytic Alkyne Reactions