A water-soluble membrane transporter for biologically relevant cations
Kylie Yang, Jessica E. Boles, Lisa J. White, Kira L. F. Hilton, Hin Yuk Lai, Yifan Long, Jennifer R. Hiscock, Cally J. E. Haynes
Abstract
Synthetic ionophores are promising therapeutic targets, yet poor water solubility limits their potential for translation into the clinic. Here we report a water-soluble, supramolecular self-associating amphiphile that functions as a cation uniporter in synthetic vesicle systems, deriving mechanistic insight through planar bilayer patch clamp experiments.
Topics & Concepts
AmphiphileChemistryVesicleSupramolecular chemistryLipid bilayerBilayerMembraneBiophysicsCombinatorial chemistryOrganic chemistryBiochemistryMoleculeBiologyPolymerCopolymerMolecular Sensors and Ion DetectionSupramolecular Self-Assembly in MaterialsLuminescence and Fluorescent Materials