Enigmazole C: A Cytotoxic Macrocyclic Lactone and Its Ring-Opened Derivatives from a New Species of <i>Homophymia</i> Sponge
Guillermo Tarazona, Rogelio Fernández, Marta Pérez, Ramón E. Millán, Carlos Jiménez, Jaime Rodrı́guez, Carmen Cuevas
Abstract
) showed cytotoxic activity in the micromolar range against A-549 (lung), HT-29 (colon), MDA-MB-231 (breast), and PSN-1 (pancreas) tumor cells.
Topics & Concepts
MoietyStereochemistryCytotoxic T cellSpongeLactoneChemistryRing (chemistry)In vitroBiologyBiochemistryOrganic chemistryBotanyMarine Sponges and Natural ProductsMicrobial Natural Products and BiosynthesisChemical synthesis and alkaloids