A pain killer without analgesic tolerance designed by co-targeting PSD-95-nNOS interaction and α2-containning GABA<sub>A</sub>Rs
Jun Li, Lin Zhang, Xu Chu, Ying‐Ying Shen, Yu‐Hui Lin, Yu Zhang, Hai‐Yin Wu, Lei Chang, Yingdong Zhang, Rong Chen, Zhengping Zhang, Chun‐Xia Luo, Fei Li, Dong‐Ya Zhu
Abstract
R simultaneously, chronic use of ZL006-05 can avoid analgesic tolerance and unwanted side effects. Therefore, we offer a novel candidate drug without analgesic tolerance for treating neuropathic pain.
Topics & Concepts
PharmacologyNeuropathic painDisinhibitionGABAA receptorAnalgesicChemistryNMDA receptorPostsynaptic potentialNeurotransmissionHyperalgesiaNeuroscienceReceptorMedicineNociceptionBiologyBiochemistryPain Mechanisms and TreatmentsIon channel regulation and functionNeuropeptides and Animal Physiology