Co-encapsulation of Cas9 mRNA and guide RNA in polyplex micelles enables genome editing in mouse brain
Saed Abbasi, Satoshi Uchida, Kazuko Toh, Theofilus A. Tockary, Anjaneyulu Dirisala, Kotaro Hayashi, Shigeto Fukushima, Kazunori Kataoka
Topics & Concepts
Cas9Subgenomic mRNAGenome editingRNACRISPRGuide RNAGenomeMessenger RNAComputational biologyChemistryBiologyMolecular biologyCell biologyGeneticsGeneCRISPR and Genetic EngineeringRNA Interference and Gene DeliveryRNA regulation and disease