Demalonylation of DDX3 by Sirtuin 5 promotes antiviral innate immune responses
Xingying He, Tianliang Li, Kewei Qin, Shiyuan Luo, Zhenjie Li, Qingqing Ji, Honghao Song, Huyang He, Hao Tang, Chaofeng Han, Hongjiao Li, Yan Luo
Abstract
: Sirt5 promotes anti- RNA and DNA virus innate immune responses by increasing TBK1 signaling through demalonylating DDX3, which identifies a novel regulatory pathway of antiviral innate immune response.
Topics & Concepts
Innate immune systemImmune systemSirtuinSirtuin 1ImmunologyInflammationBiologyDownregulation and upregulationGeneticsAcetylationGeneinterferon and immune responsesRNA regulation and diseaseCancer-related molecular mechanisms research