Toward an efficient and eco-friendly route for the synthesis of dimeric 2,4-diacetyl phloroglucinol and its potential as a SARS-CoV-2 main protease antagonist: insight from <i>in silico</i> studies
Triana Kusumaningsih, Wahyu Eko Prasetyo, Fajar Rakhman Wibowo, Maulidan Firdaus
Abstract
Dimeric 2,4-diacetyl phloroglucinol derivatives were synthesized under green chemistry protocols and found to be the potential inhibitor of <bold>3CLpro</bold> of SARS-CoV-2.
Topics & Concepts
PhloroglucinolChemistryDiacetylIn silicoCombinatorial chemistryStereochemistryAntagonistOrganic chemistryBiochemistryGeneReceptorMulticomponent Synthesis of HeterocyclesSynthesis and biological activitySynthesis of Indole Derivatives