Nitric oxide-releasing platinum(<scp>iv</scp>) prodrug efficiently inhibits proliferation and metastasis of cancer cells
Yi Dai, Yang Zhu, Junjie Cheng, Juan Shen, Hai Huang, Manman Liu, Zhaolin Chen, Yangzhong Liu
Abstract
A dual-functional Pt(iv) prodrug, Pt-furoxan, can release cytotoxic cisplatin and signaling molecule NO upon cellular internalization. NO modulates the cellular response towards cisplatin, leading to a synergistic anti-proliferation effect and a promising anti-metastasis effect both in vitro and in vivo.
Topics & Concepts
ProdrugNitric oxidePlatinumChemistryMetastasisCancer cellCancer researchCancerCancer metastasisCell biologyBiochemistryBiologyCatalysisMedicineInternal medicineOrganic chemistryMetal complexes synthesis and propertiesMagnetism in coordination complexesNitric Oxide and Endothelin Effects