Prevalence of SARS-CoV-2 antibodies among Swiss hospital workers: Results of a prospective cohort study
Philipp Köhler, Christian R. Kahlert, Johannes Sumer, Domenica Flury, Sabine Güsewell, Onício Leal Neto, Julia Notter, Werner C. Albrich, Baharak Babouee Flury, Allison McGeer, Stefan P. Kuster, Lorenz Risch, Matthias Schlegel, Pietro Vernazza
Abstract
In this prospective cohort of 1,012 Swiss hospital employees, 3 different assays were used to screen serum for SARS-CoV-2 antibodies. Seropositivity was 1%; the positive predictive values of the lateral-flow immunoassay were 64% (IgG) and 13% (IgM). History of fever and myalgia most effectively differentiated seropositive and seronegative participants.
Topics & Concepts
MedicinemyalgiaProspective cohort studyCohortCohort studyAntibodySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Internal medicineCoronavirus disease 2019 (COVID-19)ImmunoassayImmunologyDiseaseInfectious disease (medical specialty)SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesViral Infections and Immunology Research