Prebiotics alleviate cartilage degradation and inflammation in post-traumatic osteoarthritic mice by modulating the gut barrier and fecal metabolomics
Yilin Mi, Nanxing Yi, Xiaotong Xu, Fan Zeng, Naping Li, Xuyi Tan, Zhixian Gong, Ke Yan, Gaoyan Kuang, Min Lü
Abstract
) were closely associated with PTOA. Our study demonstrates that prebiotics can delay the progression of PTOA by regulating the metabolites of the gut microbiota and protecting the gut barrier, which is expected to be an intervention method for PTOA.
Topics & Concepts
OsteoarthritisInflammationGut floraCartilageMedicineImmunologyPathologyAnatomyAlternative medicineOsteoarthritis Treatment and MechanismsMetabolomics and Mass Spectrometry StudiesBone Metabolism and Diseases