High CD26 and Low CD94 Expression Identifies an IL-23 Responsive Vδ2+ T Cell Subset with a MAIT Cell-like Transcriptional Profile
Kathleen M. Wragg, Hyon‐Xhi Tan, Anne B. Kristensen, Catriona V. Nguyen-Robertson, Anthony D. Kelleher, Matthew S. Parsons, Adam K. Wheatley, Stuart P. Berzins, Daniel G. Pellicci, Stephen J. Kent, Jennifer A. Juno
Abstract
Wragg et al. identify a population of human gd T cells with striking similarities to MAIT cells. These cells dominate the cord blood Vd2 population and upregulate an effector-like program upon antigen and IL-23 stimulation, providing a potential mechanism by which cytotoxic Vd2 cells may accumulate during adolescence and adulthood.
Topics & Concepts
Cytotoxic T cellBiologyCell biologyPhenotypeEffectorPopulationAdoptive cell transferContext (archaeology)T cellImmunologyImmune systemIn vitroGeneticsGeneMedicineEnvironmental healthPaleontologyImmune Cell Function and InteractionT-cell and B-cell ImmunologyCAR-T cell therapy research