Discovery of novel tubulin inhibitors targeting the colchicine binding site via virtual screening, structural optimization and antitumor evaluation
Wei Liu, Hairui Jia, Minghao Guan, Minxuan Cui, Zhuxuan Lan, Youyou He, Zhongjie Guo, Ru Jiang, Guoqiang Dong, Shengzheng Wang
Topics & Concepts
TubulinColchicineVirtual screeningChemistryApoptosisMicrotubuleIC50Cell cycleCell cycle checkpointIn vitroMultiple drug resistanceCancer researchBiochemistryCell biologyDrug discoveryBiologyGeneticsAntibioticsSynthesis and biological activityCancer Mechanisms and TherapyClick Chemistry and Applications