Constrained TCRγδ-associated Syk activity engages PI3K to facilitate thymic development of IL-17A–secreting γδ T cells
Nital Sumaria, Stefania Martin, Daniel J. Pennington
Abstract
Thymic development of IL-17A–secreting γδ T cells requires TCR signal strength within a limited range.
Topics & Concepts
T-cell receptorSykCell biologyInterleukin 17ImmunologyBiologyT cellSignal transductionCancer researchInflammationImmune systemTyrosine kinaseImmune Cell Function and InteractionT-cell and B-cell ImmunologyImmunodeficiency and Autoimmune Disorders