Acid-sensing ion channel 1: potential therapeutic target for tumor
Ying-Hong Wang, Hong Zhou, Yancai Sun, Yan Huang
Abstract
Acidic extracellular pH is a major characteristic of tumor tissue, studies suggest that the local pH value of malignant tumor tissues is between 6.0 and 6.9. Acid-sensing ion channel 1 (ASIC1) is proton-gated cation channel activated by low extracellular pH, recently an increasing number of studies have suggested that ASIC1 is involved in different kinds of tumors, which plays an important role in the occurrence and development of tumors. Therefore, this review will summarize studies involved in ASIC1 on tumors and discuss the effect and mechanism of ASIC1 in numerous related tumors, which will provide new perspectives for tumor therapeutic targets.
Topics & Concepts
Acid-sensing ion channelExtracellularIon channelChemistryCancer researchNeuroscienceBiophysicsBiologyMedicineBiochemistryReceptorIon Transport and Channel RegulationATP Synthase and ATPases ResearchCancer, Hypoxia, and Metabolism