TKF, a mexicanolide-type limonoid derivative, suppressed hepatic stellate cells activation and liver fibrosis through inhibition of the YAP/Notch3 pathway
Ting Yang, Enyi Wu, Xiaoyun Zhu, Yingrong Leng, Shengtao Ye, Ruirui Dong, Jiaman Liu, Jiawen Zhong, Ying Zheng, Wenjun Xu, Jun Luo, Lingyi Kong, Hao Zhang
Topics & Concepts
Hepatic stellate cellHES1LimonoidGene knockdownCancer researchHepatic fibrosisCCL4In vivoFibrosisTIMP1HonokiolPharmacologyChemistryBiologyCell biologyMedicineSignal transductionPathologyNotch signaling pathwayGene expressionApoptosisBiochemistryCarbon tetrachlorideStereochemistryBiotechnologyGeneOrganic chemistryLiver physiology and pathologyPhytochemical compounds biological activitiesBioactive Compounds in Plants