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Biological sex and DNA repair deficiency drive Alzheimer’s disease via systemic metabolic remodeling and brain mitochondrial dysfunction

Tyler G. Demarest, Vijay R. Varma, Darlene Estrada, Mansi Babbar, Sambuddha Basu, Uma V. Mahajan, Ruin Moaddel, Deborah L. Croteau, Madhav Thambisetty, Mark P. Mattson, Vilhelm A. Bohr

2020Acta Neuropathologica75 citationsDOIOpen Access PDF

Topics & Concepts

Mitochondrial DNADiseaseMedicineMitochondrionBiologyNeurosciencePathologyGeneticsGeneMitochondrial Function and PathologyTryptophan and brain disordersBiochemical Acid Research Studies
Biological sex and DNA repair deficiency drive Alzheimer’s disease via systemic metabolic remodeling and brain mitochondrial dysfunction | Litcius