Design, Synthesis, biological Evaluation, and molecular docking studies of novel Pyrazolo[3,4-d]Pyrimidine derivative scaffolds as potent EGFR inhibitors and cell apoptosis inducers
Farag F. Sherbiny, Ashraf H. Bayoumi, Ahmed El-morsy, Mohamed Sobhy, Mohamed Hagras
Topics & Concepts
ChemistryHeLaPyrimidineStereochemistryIC50Lead compoundDocking (animal)GefitinibEGFR inhibitorsSorafenibCell cultureLinkerIn vitroEpidermal growth factor receptorBiochemistryReceptorCancer researchComputer scienceMedicineOperating systemGeneticsHepatocellular carcinomaBiologyNursingSynthesis and biological activityQuinazolinone synthesis and applicationsCancer therapeutics and mechanisms