Impact of Antibiotic-Resistant Bacteria on Immune Activation and Clostridioides difficile Infection in the Mouse Intestine
James W. Keith, Qiwen Dong, Matthew T. Sorbara, Simone Becattini, Jonathan K. Sia, Mergim Gjonbalaj, Ruth Seok, Ingrid M. Leiner, Eric R. Littmann, Eric G. Pamer
Abstract
Antibiotic treatment of patients undergoing complex medical treatments can deplete commensal bacterial strains from the intestinal microbiota, thereby reducing colonization resistance against a wide range of antibiotic-resistant pathogens. Loss of colonization resistance can lead to marked expansion of vancomycin-resistant Enterococcus faecium (VRE), Klebsiella pneumoniae , and Escherichia coli in the intestinal lumen, predisposing patients to bloodstream invasion and sepsis.
Topics & Concepts
ClostridioidesBiologyAntibioticsMicrobiologyBacteriaImmune systemClostridium difficileImmunologyGeneticsClostridium difficile and Clostridium perfringens researchGut microbiota and healthGastrointestinal motility and disorders