S100A11 Promotes Metastasis via AKT and ERK Signaling Pathways and Has a Diagnostic Role in Hepatocellular Carcinoma
Mei Zheng, Huan Meng, Yunhui Li, Jingren Shi, Ying Han, Changxu Zhao, Jin Chen, Jinyu Han, Jing Liang, Yuan Chen, Qiqi Liu, Yajie Wang
Abstract
cell culture model, we demonstrated that S100A11 is overexpressed in metastatic hepatoma cells, knockdown of S100A11 decreases hepatoma cells proliferation, migration, invasion, and epithelial-mesenchymal transition process by inhibiting AKT and ERK signaling pathways. Altogether, our study provides new sights into the biological function and mechanisms underlying S100A11 in promoting metastasis of HCC and explores a novel target for HCC diagnosis and treatment.
Topics & Concepts
Hepatocellular carcinomaMetastasisCancer researchProtein kinase BMAPK/ERK pathwayMedicineGene knockdownPI3K/AKT/mTOR pathwayEpithelial–mesenchymal transitionBiomarkerSignal transductionBiologyCell cultureInternal medicineCancerCell biologyGeneticsBiochemistryS100 Proteins and AnnexinsProtease and Inhibitor MechanismsThyroid Cancer Diagnosis and Treatment