Hypoxia-stimulated mesenchymal stem cell-derived exosomes loaded by adhesive hydrogel for effective angiogenic treatment of spinal cord injury
Jiafu Mu, Liming Li, Jiahe Wu, Tianchen Huang, Yu Zhang, Jian Cao, Teng Ma, Jiachen Chen, Chenyang Zhang, Xunqi Zhang, Tinghao Lu, Xianglei Kong, Jihong Sun, Jianqing Gao
Abstract
Implantation of hypoxia-stimulated mesenchymal stem cell-derived exosome encapsulated in an adhesive hydrogel induced pro-angiogenic spinal cord repair through transporting HIF-1α and upregulating vascular endothelial growth factor expression in recipient endothelial cells.
Topics & Concepts
Mesenchymal stem cellAngiogenesisMicrovesiclesSpinal cord injuryHypoxia (environmental)Hyaluronic acidMedicineStem cellVascular endothelial growth factorIn vivoInflammationStem-cell therapyRegenerative medicineCell biologySpinal cordCancer researchImmunologyChemistryPathologyBiologyAnatomymicroRNAVEGF receptorsBiochemistryGeneOxygenPsychiatryBiotechnologyOrganic chemistrySpinal Cord Injury ResearchExtracellular vesicles in diseaseMesenchymal stem cell research